There is a wealth of evidence supporting the association between regular exercise and decreased cancer risk, but how and why? And can exercise really prevent tumour growth? Well, in this video I take a look at a recent publication showing cytotoxic t cells (CD8+ T-cells) may be mediating the observed exercise-induced tumour reduction. This can be understood by appreciating the hallmarks of cancer that includes evasion of immune destruction.
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Intro – 00:00
Exercise & Cancer – 00:39
Evading immune destruction – 02:00
How exercise reduces tumour growth? – 03:57
Lactate alone? – 07:00
Unanswered questions – 07:50
My thoughts & a question – 08:30
Cytotoxic t-cells – Cite as: eLife 2020;9:e59996 DOI: 10.7554/eLife.59996
Review article –
Hallmarks of cancer
Zhang, D., Tang, Z., Huang, H. et al. Metabolic regulation of gene expression by histone lactylation. Nature 574, 575–580 (2019).
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